英语翻译Antiviral CD8+T cells are thought to play a significant

英语翻译
Antiviral CD8+T cells are thought to play a significant role in limiting the viremia of human and simian immunodeficiency virus (HIV and SIV,respectively) infections.However,it has not been possible to measure the in vivo effectiveness of cytotoxic T cells (CTLs),and hence their contribution to the death rate of CD4+T cells is unknown.Here,we estimated the ability of a prototypic antigen-specific CTL response against a well-characterized epitope to recognize and kill infected target cells by monitoring the immunodominant Mamu-A*01-restricted Tat SL8 epitope for escape from Tat-specific CTLs in SIVmac239-infected macaques.Fitting a mathematical model that incorporates the temporal kinetics of specific CTLs to the frequency of Tat SL8 escape mutants during acute SIV infection allowed us to estimate the in vivo killing rate constant per Tat SL8-specific CTL.Using this unique data set,we show that at least during acute SIV infection,certain antiviral CD8+T cells can have a significant impact on shortening the longevity of infected CD4+T cells and hence on suppressing virus replication.Unfortunately,due to viral escape from immune pressure and a dependency of the effectiveness of antiviral CD8\1+T-cell responses on the availability of sufficient CD4+T cells,the impressive early potency of the CTL response may wane in the transition to the chronic stage of the infection.
直接用翻译软件翻译的请绕道，我也有谷歌有道灵格斯，请翻译成正常能读懂的文字。

Antiviral CD8+T cells are thought to play a significant role in limiting the viremia of human and simian immunodeficiency virus (HIV and SIV, respectively) infections.抗病毒CD8+T细胞被认为在限制人和动物免疫缺陷病毒（分别为HIV和SIV【即艾滋病—译者注】）感染病毒血症中起着重要的作用.　　However, it has not been possible to measure the in vivo effectiveness of cytotoxic T cells (CTLs), and hence their contribution to the death rate of CD4+T cells is unknown.然而还没有可能去测出体内的细胞毒性T淋巴细胞（CTLs）,因此这些细胞对CD4+T细胞死亡率的影响尚未可知.　　Here, we estimated the ability of a prototypic antigen-specific CTL response against a well-characterized epitope to recognize and kill infected target cells by monitoring the immunodominant Mamu -A *01-restricted Tat SL8 epitope for escape from Tat-specific CTLs in SIVmac239-infected macaques.这里,借助监测免疫显性基因Mamu【见注】A*01范围受限制的Tat SL8表位的方法,以达到在SIV mac239感染的猕猴中幸免于Tat特性的CTLs感染,我们对照良性表位（又称抗原决定基—译者注）估计了典型的抗原特性的CTL的反应,目的是为了认识并杀死被感染的靶细胞.　　Fitting a mathematical model that incorporates the temporal kinetics of specific CTLs to the frequency of Tat SL8 escape mutants during acute SIV infection allowed us to estimate the in vivo killing rate constant per Tat SL8-specific CTL.与把特殊CTLs的瞬间动力学并入到在急性SIV感染期间Tat SL8逸出突变型的数学模型相配合,允许我们估计每个SL8-特殊CTL的体内杀死率的恒定值.　　Using this unique data set, we show that at least during acute SIV infection, certain antiviral CD8+T cells can have a significant impact on shortening the longevity of infected CD4+T cells and hence on suppressing virus replication.利用这个唯一的数据集,至少在急性感染期间,某些抗病毒CD8+T细胞会对被感染的CD4+T细胞从而抑制病毒复制缩短寿命具有重大影响.　　Unfortunately, due to viral escape from immune pressure and a dependency of the effectiveness of antiviral CD8+T-cell responses on the availability of sufficient CD4+T cells, the impressive early potency of the CTL response may wane in the transition to the chronic stage of the infection.令人遗憾的是,由于病毒幸免于免疫困扰和抗病毒CD8+T细胞对足够的CD4+T细胞反应效果的依赖,影响深刻的CTL反应早期效力可能会在转变为这种感染的慢性期中减小.　　【注释】　　HIV：人体免疫缺陷病毒　　SIV：动物体免疫缺陷病毒　　Mamu：千分之一原子质量单位　　CTL：细胞毒性T淋巴细胞 专业性太强,有的地方翻译得可能不十分准确,仅供参考.