大师作文网英语翻译Pre-dosing of athymic mice and Ifnar-CD46Ge mice with po
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英语翻译
Pre-dosing of athymic mice and Ifnar-CD46Ge mice with poly(I) prolonged the circulatory half-life of MV,resulting in a 15-fold and 4-fold increase,respectively,of MV levels in the blood early post virus infusion.Though modest,this increase in MV circulating half-life had an impact on virus delivery to tumors,enhancing virus delivery to and infection of tumor xenografts.Importantly,poly(I) pre-dosing resulted in superior tumor control by MV-NIS in two different models of human malignancy (ovarian and myeloma),at least at the early time points post delivery.As the aim of the experiment was to evaluate the impact of poly(I) on MV delivery,tumor-bearing mice were given only one dose of MV-NIS and the survival curves of mice treated with or without poly(I) were not significantly different at the end of the experiment.Nonetheless,this single delivery of MV at subtherapeutic levels clearly demonstrated the advantage of incorporating poly(I) in the treatment regimen to increase the bioavailability of the systemically applied virus.
Pre-dosing of athymic mice and Ifnar-CD46Ge mice with poly(I) prolonged the circulatory half-life of MV,resulting in a 15-fold and 4-fold increase,respectively,of MV levels in the blood early post virus infusion.Though modest,this increase in MV circulating half-life had an impact on virus delivery to tumors,enhancing virus delivery to and infection of tumor xenografts.Importantly,poly(I) pre-dosing resulted in superior tumor control by MV-NIS in two different models of human malignancy (ovarian and myeloma),at least at the early time points post delivery.As the aim of the experiment was to evaluate the impact of poly(I) on MV delivery,tumor-bearing mice were given only one dose of MV-NIS and the survival curves of mice treated with or without poly(I) were not significantly different at the end of the experiment.Nonetheless,this single delivery of MV at subtherapeutic levels clearly demonstrated the advantage of incorporating poly(I) in the treatment regimen to increase the bioavailability of the systemically applied virus.
裸鼠和聚（一）延长循环半衰期的MV,导致增加了15倍和4倍,分别压后早期血液中的病毒输液水平,IFNAR CD46Ge小鼠给药前.虽然温和,这个MV的循环半衰期增加了对病毒传递到肿瘤的影响,提高传播病毒和肿瘤异种移植感染.更重要的是,预投加聚（一）导致上级MV- NIS的肿瘤控制在两个不同的人类恶性肿瘤模型（卵巢癌和骨髓瘤）,至少在早期的时间点交付后.作为实验的目的是评价聚（一）上的MV交付的影响,荷瘤小鼠分别给予MV- NIS和聚（一）有或没有处理过的小鼠的生存曲线只有一个剂量不显著在实验结束时的不同.然而,这个MV在亚治疗水平的交单,清楚地表明纳入聚（一）在治疗方案,以增加系统应用病毒的生物利用度的优势
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