大师作文网英语翻译To determine the absolute bioavailability of moxifloxaci
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英语翻译
To determine the absolute bioavailability of moxifloxacin,this open-label,randomized,crossover
study compared the pharmacokinetic characteristics of a single lOO-mg dose administered either orally or intravenously as a 60-minute infusion in 10 healthy malevolunteers (mean age [+ SD],29.3 + 7.1
years; mean weight [+ SD],77.7 + 8.7kg).Geometric mean values for oral/IV moxifloxacin were as follows:peak serum concentration,1.15/l .34 mg/L,and area under the concentration-time curve over
48 hours,9.86/10.89 mg*h/L.The geometric mean absolute bioavailability of oral moxifloxacin was 9 1.8%.Mean renal clearance was approximately 2.3 L/h after administration of both the single oral and
IV formulations,which suggests lack of active tubular secretion of moxifloxacin.Both the oral and IV formulations were well tolerated,with 5 reported possible or probable drug-related adverse events; they
included headache,nausea,and localized urticaria.In summary,a single oral dose of moxifloxacin was extensively absorbed in healthy young men.Further studies are necessary in actual patients to confirm the viability of IV to oral conversion at the same dose of moxifloxacin
To determine the absolute bioavailability of moxifloxacin,this open-label,randomized,crossover
study compared the pharmacokinetic characteristics of a single lOO-mg dose administered either orally or intravenously as a 60-minute infusion in 10 healthy malevolunteers (mean age [+ SD],29.3 + 7.1
years; mean weight [+ SD],77.7 + 8.7kg).Geometric mean values for oral/IV moxifloxacin were as follows:peak serum concentration,1.15/l .34 mg/L,and area under the concentration-time curve over
48 hours,9.86/10.89 mg*h/L.The geometric mean absolute bioavailability of oral moxifloxacin was 9 1.8%.Mean renal clearance was approximately 2.3 L/h after administration of both the single oral and
IV formulations,which suggests lack of active tubular secretion of moxifloxacin.Both the oral and IV formulations were well tolerated,with 5 reported possible or probable drug-related adverse events; they
included headache,nausea,and localized urticaria.In summary,a single oral dose of moxifloxacin was extensively absorbed in healthy young men.Further studies are necessary in actual patients to confirm the viability of IV to oral conversion at the same dose of moxifloxacin
测定莫西沙星的绝对生物利用度,这个开放标签,随机,crossoverstudy相比一个单一的100毫克剂量口服或静脉注射,在10名健康调节60分钟输注的药代动力学特征（平均年龄【+ SD ],29.3 + 7.1years；平均体重[清] 77.7 + +,8.7kg）.口腔/四莫西沙星几何平均值分别为：血浆峰浓度,1.15/l.34毫克/升,和区域的浓度-时间曲线下over48小时,9.86/10.89毫克* H／L,几何平均绝对生物利用度为9,口服莫西沙星1.8%.平均肾清除率的单次口服andiv制剂给药后约2.3升/小时,这表明莫西沙星主动肾小管分泌缺乏.无论是口服和静脉制剂耐受性良好,5例可能或很可能与药物相关的不良事件；他们包括头痛,恶心,和局限性荨麻疹.总之,单剂量口服莫西沙星是广泛吸收健康青年男性.有必要进一步研究,在实际的患者确定四活力口服莫西沙星同样剂量的转换
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