英语翻译We used reverse-phase protein microarray analysis of las

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英语翻译
We used reverse-phase protein microarray analysis of laser capture microdissected CRC tumor specimens to profile broad cell signaling pathways from patients who presented with liver metastasis versus patients who remained recurrence free after follow-up.Our results indicate that members of the EGFR and COX2 signaling pathways appear differentially activated in the primary tumors of patients with synchronous metastatic disease.If validated in larger study sets,this pathway defect might be useful as a prognostic clinical tool as well as a guide to potential therapeutic intervention strategies that target occult disease and/or preventative measure.

我们使用配置文件广泛细胞信号转导通路提供病人随访后残留复发自由与肝转移的病人从反相蛋白微阵列分析的激光捕获 microdissected CRC 肿瘤标本.我们的实验结果表示表皮生长因子和 COX2 的信号通路的成员出现在原发性肿瘤同步转移病患者中差异激活.如果验证中较大的研究集,此途径缺陷可能预后的临床工具以及目标隐性疾病和/或预防性措施的可能治疗干预策略的指南很有用.
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